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Disease Burden

Disease incidence rates similar in developing and developed world

Because clean water and good hygiene practices have little effect on disease transmission, rates of rotavirus disease are similar in developing and developed countries.

Rotavirus is the most common cause of severe gastroenteritis in infants and young children in the United States. Rotavirus gastroenteritis (RGE) has significant consequences for infants and young children in the United States accounting for up to 272,000 ED visits and 70,000 hospitalizations annually. [2]

Infants < 6 months of age at risk for hospitalization, US

Adapted from Parashar UD, et al. JID. 1998;177:13–17.

Peak season: rotavirus responsible for about 70% of pediatric hospitalizations for acute gastroenteritis [2,16]

In the US, rotavirus accounts for approximately 70% of hospitalizations for gastroenteritis in children <5 years of age, during the peak winter season. [2]

In data from this surveillance study at 3 pediatric hospitals from November 1997 to June 1998, rotavirus accounted for the following percentages of all pediatric acute gastroenteritis hospitalizations [2,16]:

  • 71% during the peak month of March
  • 75% in April
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Indications and Usage

ROTARIX is indicated for the prevention of rotavirus gastroenteritis caused by G1 and non-G1 types (G3, G4, and G9) when administered as a 2-dose series in infants and children.

 

Important Safety Information

  • In clinical studies, common adverse events were fussiness/irritability, cough/runny nose, fever, loss of appetite, and vomiting.
  • History of uncorrected congenital malformation of the gastrointestinal tract is a contraindication.
  • Previous hypersensitivity to any component of ROTARIX, including latex rubber, should be reviewed prior to administration.
  • Administration in infants suffering from acute diarrhea or vomiting should be delayed.
  • Safety and effectiveness in infants with chronic gastrointestinal disorders, or with known primary or secondary immunodeficiencies, have not been evaluated.

Download Complete Prescribing Information for ROTARIX
Order ROTARIX Keep up-to-date on the latest developments on ROTARIX and rotavirus prevention ROTARIX provides significant reduction in serious consequences of RGE. [1,3]